By Silvio Garattini
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Additional info for Advances in Pharmacology and Chemotherapy Volume 17
Also, it should be noted that backbone differences observed in the X-ray structures cannot be unambiguously assigned to the effects of NADPH binding rather than to species differences. , 1975). The overall connectivity and structure of DHFR was compared by Matthews et al. (1977) with that of a number of NADH-dependent dehydrogenases using topological maps. It was found that the spatial arrangement but not the connectivity was nearly the same for the two enzyme classes: this led to the conclusion that a similar preferred mononucleotide binding structure had been arrived at by convergent evolution.
3 shows that Thr-136 is totally conserved, the most recent results indicate that Asp-29 is not and hence proposed roles in catalysis and inhibitor binding need to be reevaluated. 2. Specific Binding Interactions While the X-ray studies have provided evidence for specific binding interactions, they cannot provide information about the stabilizing influence of individual interactions in the total binding scheme which is of the utmost importance chemically and, hence, pharmacologically. Experimental results for the binding energetics, including cooperative binding of inhibitor and substrate fragments and the relative importance of the various binding areas, are given in Section III,B,4.
C. Outlines of Clinical Cancer Protocols . . . . ICRDB Data Bases for Cancer Researchers . . . . I. Introduction 11. Collection of Data 111. . . . . . . . . . . . IV. Searching of Cancer Data Bases and Indexing of Biomedical Information V. Publications Used to Disseminate Cancer-Related Information Automatically . . . . . . . . . . . A. CANCERGRAMS . . . . . . . . . B. Special Listings . . . . . . . . . C. Compilation of Clinical Protocol Summaries .
Advances in Pharmacology and Chemotherapy Volume 17 by Silvio Garattini