Advances in Low-Temperature Biology, Volume 3 by Peter L. Steponkus PDF

By Peter L. Steponkus

ISBN-10: 0080552285

ISBN-13: 9780080552286

ISBN-10: 0762301600

ISBN-13: 9780762301607

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Extra resources for Advances in Low-Temperature Biology, Volume 3

Sample text

Also, only one animal exposed to 80 minutes of asanguineous perfusion at zero percent hematocrit was able to survive for 24 hours postoperatively and subsequently died of wet lung syndrome. The main problems reported in these studies were of a cardiac nature, described as the inability to defibrillate the heart on rewarming. Haff et al. used pooled homologous plasma expanded with Ringer's solution as a cold perfusate together with a similar solution, but with increased potassium concentration, as the main perfusate.

Levels of serum enzymes that are recognized indicators of tissue function were monitored for up to three weeks post-operatively in the surviving dogs. These analyses showed that, in general, the UHBS technique led to increased levels of serum enzymes reflecting some perturbation of organ function. The immediate post-operative concentrations of liver, heart, and brain enzymes were statistically higher in dogs from Group I compared with Group II. , 1992). The results of this pilot feasibility study to evaluate a technique of complete blood substitution under conditions of ultraprofound hypothermia clearly demonstrated that the procedure yields an encouraging number of survivors after 2 to 3 hours of hypothermic cardiac arrest.

E. BAILES ferent colloids may be of less importance than other qualities, and non-antigenic clinical grade dextran-40 is used in Hypothermosol for the reasons outlined above. Any dextran that should permeate into the interstitial space during the hypothermic procedure will also be readily eluted upon return to physiological conditions. Another possible advantage of the use of dextran is that the viscosity of the blood substitute will not be as high as with some other colloids such as HES; this is also an important consideration for rheological aspects of whole-body or even just cerebral perfusion.

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Advances in Low-Temperature Biology, Volume 3 by Peter L. Steponkus


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